Tadano Toshihiro, Takahashi Hiroki, Sugawara Kaori, Sugimura Mikako, Iwabuchi Masahiro, Mano Yutaka, Ukai Katsuaki, Tadokoro Keiichi, Mori Yoshimasa
Department of Gastroenterology, Sendai Medical Center.
Nihon Shokakibyo Gakkai Zasshi. 2013 Oct;110(10):1783-9.
A 23-year-old woman was admitted with a relapse of ulcerative colitis. Tacrolimus therapy was initiated following inadequate response to corticosteroid therapy. Although the symptoms partially improved, she suddenly developed severe pain localized to the lower limbs on day 16 of tacrolimus therapy. By day 17, she was unable to move. Magnetic resonance imaging revealed born marrow edema in the lower limbs. We suspected calcineurin-inhibitor induced pain syndrome (CIPS) due to tacrolimus therapy. The pain improved within approximately four weeks of tacrolimus cessation. CIPS that is not associated with organ transplantation is a rare occurrence. Here we report a rare case of CIPS that was caused by tacrolimus therapy in a patient with ulcerative colitis.
一名23岁女性因溃疡性结肠炎复发入院。在对皮质类固醇治疗反应不佳后开始使用他克莫司治疗。尽管症状部分改善，但在他克莫司治疗第16天，她突然出现下肢严重疼痛。到第17天，她无法活动。磁共振成像显示下肢骨髓水肿。我们怀疑是他克莫司治疗引起的钙调神经磷酸酶抑制剂诱导的疼痛综合征（CIPS）。停用他克莫司后约四周内疼痛有所改善。与器官移植无关的CIPS很少见。在此，我们报告一例由他克莫司治疗引起的溃疡性结肠炎患者CIPS罕见病例。
