Shimamoto Yukiko, Mizukoshi Masato, Kuroi Akio, Imanishi Toshio, Takeshita Tatsuya, Terada Masaki, Akasaka Takashi
Wakayama-Minami Radiology Clinic.
Int Heart J. 2013;54(5):273-8. doi: 10.1536/ihj.54.273.
Metabolic syndrome (MS) is currently considered to be a risk factor for arteriosclerotic disease. The accumulation of visceral fat leads to arteriosclerotic disease after other risk factors have developed and either direct or mutual effects occur. The aim of this study was to verify whether visceral fat serves as an independent coronary risk factor. A total of 3157 patients who had undergone multi-detector computed tomography (MDCT) were analyzed via computed tomographic angiography and the measurement of their visceral fat area. Coronary arteries with > 70% stenosis were considered to be significant. The visceral fat area was measured at the umbilical level, and an area of 100 cm2 or more was defined as visceral obesity. Coronary risk factors (ie, hypertension, dyslipidemia, diabetes mellitus, family history, and smoking) were obtained from the patient medical records. The patients were divided into two groups: a visceral obesity group, 1130 patients (137.0 ± 31.1 cm2) and a nonvisceral obesity group, 2027 patients (57.3 ± 25.8 cm2). A significant difference in the incidence of coronary stenosis between the two groups was observed. According to multivariable analysis, the factors affecting coronary stenosis were age, gender, dyslipidemia, diabetes mellitus, and the ratio of visceral to subcutaneous fat. Visceral obesity was not found to be an independent coronary risk factor. Visceral obesity demonstrated the predominant presence of coronary risk factors.
代谢综合征（MS）目前被认为是动脉粥样硬化疾病的一个危险因素。在其他危险因素出现并产生直接或相互作用后，内脏脂肪的积累会导致动脉粥样硬化疾病。本研究的目的是验证内脏脂肪是否为独立的冠状动脉危险因素。通过计算机断层血管造影和测量内脏脂肪面积，对总共3157例接受多排螺旋计算机断层扫描（MDCT）的患者进行了分析。狭窄程度>70%的冠状动脉被认为具有显著性。在内脏水平测量内脏脂肪面积，100 cm²或更大的面积被定义为内脏肥胖。冠状动脉危险因素（即高血压、血脂异常、糖尿病、家族史和吸烟）从患者病历中获取。患者被分为两组：内脏肥胖组，1130例患者（137.0±31.1 cm²）和非内脏肥胖组，2027例患者（57.3±25.8 cm²）。观察到两组之间冠状动脉狭窄发生率存在显著差异。根据多变量分析，影响冠状动脉狭窄的因素为年龄、性别、血脂异常、糖尿病以及内脏与皮下脂肪的比例。未发现内脏肥胖是独立的冠状动脉危险因素。内脏肥胖表现出冠状动脉危险因素的主要存在。
