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百日咳加强疫苗接种与速发型超敏反应。

Pertussis booster vaccination and immediate hypersensitivity.

作者信息

Gifford C G, Gonsior E C, Villacorte G V, Bewtra A, Townley R G

出版信息

Ann Allergy. 1985 Jun;54(6):483-5.

PMID:2409847
Abstract

Twelve non-atopic and 27 atopic preschool children were studied to determine the effect of pertussis booster vaccination on cutaneous histamine sensitivity and IgE antibody response to the naturally-occurring ragweed aeroallergen. Prick tests of histamine and ragweed extract, as well as ragweed-RAST, were performed prior to, and after, their booster injections. Ragweed skin tests and RAST were not repeated until 2 weeks after the end of ragweed pollination. None of the parameters changed significantly in either group regardless of the type of immunization administered.

摘要

对12名非特应性和27名特应性学龄前儿童进行了研究,以确定百日咳加强疫苗接种对皮肤组胺敏感性以及对天然存在的豚草气传变应原的IgE抗体反应的影响。在加强注射之前和之后,进行了组胺和豚草提取物的点刺试验以及豚草RAST试验。直到豚草授粉结束后2周才重复进行豚草皮肤试验和RAST试验。无论接种的免疫类型如何,两组的任何参数均未发生显著变化。

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引用本文的文献

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Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies.百日咳博德特氏菌及其他博德特氏菌亚种引起的呼吸道感染的分子发病机制、流行病学及临床表现
Clin Microbiol Rev. 2005 Apr;18(2):326-82. doi: 10.1128/CMR.18.2.326-382.2005.
2
Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE responses against pertussis toxin but not against common allergens.用无细胞百日咳疫苗对儿童进行加强免疫可增强Th2细胞因子的产生以及针对百日咳毒素的血清IgE反应,但对常见过敏原则无此作用。
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3
Does pertussis infection induce manifestation of allergy?
百日咳感染会引发过敏表现吗?
Clin Investig. 1993 Mar;71(3):208-13. doi: 10.1007/BF00180103.