一名年轻旅行者口服疫苗后出现伤寒热：病例报告
A young traveller presenting with typhoid fever after oral vaccination: a case report.
作者信息
Grimm Martin, Lübbert Christoph, Mössner Joachim, Weis Sebastian
机构信息
Department of Internal Medicine, Neurology and Dermatology, Medical Intensive Care Unit, University Hospital Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany.
出版信息
J Med Case Rep. 2013 Oct 7;7:237. doi: 10.1186/1752-1947-7-237.
INTRODUCTION
Typhoid fever is one of the most common vaccine-preventable diseases in travellers returning from tropical destinations. However, immunity and the immune response to infection are barely understood.
CASE PRESENTATION
We report a case of tyhoid fever in a 29-year-old Caucasian, previously healthy woman who did not develop protective immunity or seroconversion of H or O antibodies neither after vaccination with the oral Ty21 vaccine, nor after infection with Salmonella typhi.
CONCLUSIONS
This case highlights the insufficiencies of the current vaccination and the lack of a reliable, rapid serologic diagnostic tool for typhoid fever. With this case report, we aim to sensitize the reader that typhoid fever has to be taken into account as a differential diagnosis in patients even after vaccination and with negative serological test results.
引言
伤寒热是从热带地区返回的旅行者中最常见的疫苗可预防疾病之一。然而，人们对免疫力以及感染后的免疫反应了解甚少。
病例报告
我们报告一例伤寒热病例，患者为一名29岁的白种女性，此前身体健康。她在接种口服Ty21疫苗后，以及感染伤寒沙门氏菌后，均未产生保护性免疫或H或O抗体的血清转化。
结论
该病例凸显了当前疫苗接种的不足，以及缺乏一种可靠、快速的伤寒热血清学诊断工具。通过本病例报告，我们旨在提醒读者，即使在接种疫苗且血清学检测结果为阴性的患者中，也必须将伤寒热作为鉴别诊断考虑在内。
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