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东非地区HIV患者管理中CD4细胞计数的应用:一项多中心研究。

The presence of CD4 counts for the management of HIV patients in East Africa: a multicentred study.

作者信息

Harding Richard, Simms Victoria, Penfold Suzanne, Downing Julia, Powell Richard A, Mwangi-Powell Faith, Namisango Eve, Moreland Scott, Gikaara Nancy, Atieno Mackuline, Kataike Jeniffer, Nsubuga Clare, Munene Grace, Banga Geoffrey, Higginson Irene J

机构信息

a Department of Palliative Care, Policy & Rehabilitation, King's College London , Cicely Saunders Institute , London , UK.

出版信息

AIDS Care. 2014;26(5):613-8. doi: 10.1080/09540121.2013.844765. Epub 2013 Oct 8.

Abstract

New WHO guidance stipulates six-monthly CD4 testing and treatment initiation at CD4 less than 350. This study aimed to determine the presence of CD4 results in patient records across five care facilities in Kenya, and to identify factors associated with the presence of CD4 count. This is a cross-sectional study of consecutive outpatients. Participants completed self-reported outcomes of demographics, and both physical and mental health dimensions of quality of life and function; charts were reviewed for a CD4 count in the previous 13 months; 548 patients participated. For those diagnosed during the 13-month study period, 7.1% of the sample had no CD4 result on record. For those diagnosed prior to the study, 8.7% had no result. Multivariate logistic regression revealed that 30 days post-HIV diagnosis, facility and antiretroviral therapy use were associated with the odds of having a CD4 result on file. At six months, poverty and prevalence of multidimensional problems were associated with lack of CD4 result. For those diagnosed prior to the observation period, education level was associated with more infrequent CD4 counts, and facility and number of dependants were associated with odds of a CD4 result within six months. Our data suggest inconsistencies in CD4 results availability within and between facilities. Implementation of new guidance will require a shift in practice.

摘要

世界卫生组织的新指南规定每六个月进行一次CD4检测,并在CD4低于350时开始治疗。本研究旨在确定肯尼亚五个医疗机构患者记录中CD4检测结果的存在情况,并确定与CD4计数结果存在相关的因素。这是一项对连续门诊患者的横断面研究。参与者完成了关于人口统计学、生活质量和功能的身心健康维度的自我报告结果;查阅病历以获取前13个月的CD4计数;共有548名患者参与。在13个月的研究期间被诊断出的患者中,7.1%的样本记录中没有CD4检测结果。在研究之前被诊断出的患者中,8.7%没有检测结果。多因素逻辑回归显示,在HIV诊断后30天,医疗机构和抗逆转录病毒疗法的使用与有CD4检测结果记录的几率相关。在六个月时,贫困和多维度问题的患病率与没有CD4检测结果相关。对于在观察期之前被诊断出的患者,教育水平与CD4计数不频繁相关,医疗机构和受抚养人数与六个月内有CD4检测结果的几率相关。我们的数据表明,各医疗机构内部以及不同医疗机构之间在提供CD4检测结果方面存在不一致。实施新指南将需要改变实践。

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