Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 4678601, Japan.
World J Surg Oncol. 2013 Oct 7;11:263. doi: 10.1186/1477-7819-11-263.
Primary gastric small cell carcinoma is a rare and aggressive malignant disease with a poor prognosis that was first reported in 1976 by Matsusaka et al. The incidence is very low and the clinicopathological features are similar to those of small cell lung carcinoma.We herein report a case of successful treatment by combination chemotherapy consisting of irinotecan hydrochloride and cisplatin for primary gastric small cell carcinoma. The patient was a 71-year-old male who was admitted to a local hospital with anemia. Gastrointestinal endoscopy revealed the presence of advanced gastric carcinoma at the upper region of the stomach. The patient underwent surgery, and the pathological diagnosis was small cell carcinoma due to the presence of the typical features of small round cells with scant cytoplasm that were positive for synaptophysin and chromogranin A in the resected specimen. The patient underwent subsequent combination chemotherapy, which provided him with over 1 year of survival and a good quality of life. We also present a review of the literature regarding chemotherapy for primary gastric small cell carcinoma.
原发性胃小细胞癌是一种罕见且侵袭性强的恶性疾病，预后较差，于 1976 年由 Matsusaka 等人首次报道。其发病率非常低，临床病理特征与小细胞肺癌相似。本文报告了一例原发性胃小细胞癌采用盐酸伊立替康和顺铂联合化疗成功治疗的病例。患者为 71 岁男性，因贫血入住当地医院。胃肠内镜检查显示胃上部存在进展期胃癌。患者接受了手术治疗，切除标本的病理诊断为小细胞癌，因为存在典型的小圆细胞特征，细胞质稀少，突触素和嗜铬粒蛋白 A 阳性。随后患者接受了联合化疗，生存时间超过 1 年，生活质量良好。我们还对原发性胃小细胞癌的化疗进行了文献复习。
