狐说：叉头转录因子对促性腺激素基因表达的调控。
Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors.
机构信息
Department of Reproductive Medicine and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA 92093, United States.
出版信息
Mol Cell Endocrinol. 2014 Mar 25;385(1-2):62-70. doi: 10.1016/j.mce.2013.09.034. Epub 2013 Oct 4.
Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are produced by pituitary gonadotrope cells and are required for steroidogenesis, the maturation of ovarian follicles, ovulation, and spermatogenesis. Synthesis of LH and FSH is tightly regulated by a complex network of signaling pathways activated by hormones including gonadotropin-releasing hormone, activin and sex steroids. Members of the forkhead box (FOX) transcription factor family have been shown to act as important regulators of development, homeostasis and reproduction. In this review, we focus on the role of four specific FOX factors (FOXD1, FOXL2, FOXO1 and FOXP3) in gonadotropin hormone production and discuss our current understanding of the molecular function of these factors derived from studies in mouse genetic and cell culture models.
黄体生成素 (LH) 和卵泡刺激素 (FSH) 由垂体促性腺细胞产生，是甾体激素合成、卵母细胞成熟、排卵和精子发生所必需的。LH 和 FSH 的合成受到由包括促性腺激素释放激素、激活素和性激素在内的激素激活的复杂信号通路网络的严格调控。叉头框 (FOX) 转录因子家族的成员已被证明是发育、内稳态和生殖的重要调节因子。在这篇综述中，我们重点介绍了四个特定的 FOX 因子（FOXD1、FOXL2、FOXO1 和 FOXP3）在促性腺激素产生中的作用，并讨论了我们从鼠遗传和细胞培养模型研究中得出的这些因子的分子功能的现有认识。
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