FOXP3 N 端结构域在 T 调节/抑制细胞免疫调控中的分子和生物学作用。
Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells.
机构信息
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104-6082, USA.
出版信息
Exp Mol Pathol. 2012 Dec;93(3):334-8. doi: 10.1016/j.yexmp.2012.09.013. Epub 2012 Oct 2.
Abstract
Regulatory T (Treg) cells are essential in preventing the host from developing certain autoimmune diseases and limiting excessive immune responses against pathogens. The normal function of most Treg cells requires sustained expression of functional FOXP3, a member of the FOXP family transcription factors. FOXP3 is distinct from other subfamily members because of its unique proline rich amino (N)-terminal domain. Mutations in this region are occasionally identified in certain patients with X-linked autoimmunity-allergic dysregulation syndrome (XLAAD) and similar mutations also increase susceptibility of autoimmune diseases in rodent models. Previous analyses of the FOXP3 N-terminal domain revealed a role in nuclear import, interaction with other transcription factors, and as sites of specific post-translational modifications of FOXP3 that contribute to FOXP3 stability.
摘要
调节性 T（Treg）细胞对于防止宿主发生某些自身免疫性疾病和限制针对病原体的过度免疫反应至关重要。大多数 Treg 细胞的正常功能需要持续表达功能 FOXP3，FOXP3 是 FOXP 家族转录因子的成员之一。由于其独特的富含脯氨酸的氨基（N）-末端结构域，FOXP3 与其他亚家族成员不同。在某些 X 连锁自身免疫-过敏失调综合征（XLAAD）患者中偶尔会发现该区域的突变，类似的突变也会增加啮齿动物模型中自身免疫性疾病的易感性。对 FOXP3 N 末端结构域的先前分析表明其在核输入、与其他转录因子相互作用以及作为 FOXP3 的特定翻译后修饰的位点中发挥作用，这些修饰有助于 FOXP3 的稳定性。
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