Barrett Claire L, Louw Vernon J, Webb Michael J
Department of Internal Medicine, University of the Free State, Bloemfontein, South Africa.
Transfus Apher Sci. 2013 Dec;49(3):397-402. doi: 10.1016/j.transci.2013.09.003. Epub 2013 Sep 20.
Hyperleukocytosis is a rare but potentially serious complication of haematological malignancies. It is usually treated with rehydration, prevention of tumour lysis syndrome and the administration of cytotoxic therapy. Leukapheresis may be life-saving in emergency cases. In this article we describe how, in a resource-limited setting where leukapheresis was not available, manual exchange transfusion was utilised as a life-saving intervention in three patients with different haematological malignancies complicated by hyperleukocytosis. Further we outline the procedure that was carried out and evaluated possible complications associated with this rarely used practice.
高白细胞血症是血液系统恶性肿瘤一种罕见但可能严重的并发症。通常采用补液、预防肿瘤溶解综合征及给予细胞毒性疗法进行治疗。在紧急情况下，白细胞去除术可能挽救生命。在本文中，我们描述了在白细胞去除术无法开展的资源有限环境中，如何对三名患有不同血液系统恶性肿瘤并合并高白细胞血症的患者采用手工换血作为挽救生命的干预措施。此外，我们概述了所实施的操作程序，并评估了与这种很少使用的做法相关的可能并发症。
