Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800, Kongens Lyngby, Denmark.
Calcif Tissue Int. 2014 Feb;94(2):248-57. doi: 10.1007/s00223-013-9806-7. Epub 2013 Oct 8.
Strontium has recently been introduced as a pharmacological agent for the treatment and prevention of osteoporosis. We determined the localization of strontium incorporated into bone matrix from dogs treated with Sr malonate by X-ray absorption spectroscopy. A new approach for analyzing the X-ray absorption spectra resulted in a compositional model and allowed the relative distribution of strontium in the different bone components to be estimated. Approximately 35-45% of the strontium present is incorporated into calcium hydroxyapatite (CaHA) by substitution of some of the calcium ions occupying highly ordered sites, and at least 30% is located at less ordered sites where only the first solvation shell is resolved, suggesting that strontium is surrounded by only oxygen atoms similar to Sr(2+) in solution. Strontium was furthermore shown to be absorbed in collagen in which it obtains a higher structural order than when present in serum but less order than when it is incorporated into CaHA. The total amount of strontium in the samples was determined by inductively coupled plasma mass spectrometry, and the amount of Sr was found to increase with increasing dose levels and treatment periods, whereas the relative distribution of strontium among the different components appears to be independent of treatment period and dose level.
锶最近被引入作为治疗和预防骨质疏松症的药物。我们通过 X 射线吸收光谱法确定了用丙二酸盐处理的狗的骨基质中掺入的锶的定位。一种新的分析 X 射线吸收光谱的方法导致了一种组成模型，并允许估计锶在不同骨成分中的相对分布。大约 35-45%的存在的锶通过取代占据高度有序位置的一些钙离子而掺入到钙羟磷灰石（CaHA）中，并且至少 30%位于不太有序的位置，在这些位置中仅解析了第一个溶剂化壳，表明锶仅被类似于溶液中的 Sr(2+)的氧原子包围。此外，锶被证明被胶原吸收，其中它获得比存在于血清中更高的结构有序性，但比掺入 CaHA 时的有序性低。通过电感耦合等离子体质谱法确定了样品中的总锶量，发现随着剂量水平和治疗期的增加，Sr 的量增加，而锶在不同成分之间的相对分布似乎与治疗期和剂量水平无关。
