Gautret B, Schmitt H
Eur J Pharmacol. 1985 May 8;111(2):263-6. doi: 10.1016/0014-2999(85)90766-6.
Dynorphin-(1-13) (i.v.) induced bradycardia and hypotension in artificially ventilated anaesthetized rats. These effects were prevented by MRZ 2266 BS. The bradycardia was inhibited by bilateral vagotomy whereas the fall in blood pressure was not sensitive to bilateral vagotomy and chlorpheniramine treatment. In pithed rats, dynorphin-(1-13) reduced heart rate. This bradycardia was prevented by MRZ 2266 BS but not by tertatolol and cimetidine. It is suggested that the dynorphin-(1-13)-induced effects result from the stimulation of central and cardiac kappa-opiate receptors.
强啡肽 -（1 - 13）（静脉注射）可使人工通气的麻醉大鼠出现心动过缓和低血压。这些效应可被MRZ 2266 BS阻断。双侧迷走神经切断可抑制心动过缓，而血压下降对双侧迷走神经切断和氯苯那敏治疗不敏感。在脊髓切断的大鼠中，强啡肽 -（1 - 13）可降低心率。这种心动过缓可被MRZ 2266 BS阻断，但不能被替他洛尔和西咪替丁阻断。提示强啡肽 -（1 - 13）诱导的效应是由中枢和心脏κ-阿片受体的刺激所致。
