产前和产后营养不足对大鼠小脑皮质发育的影响。II. 组织化学观察。
The effect of pre- and postnatal undernutrition on the development of the cerebellar cortex in the rat. II. Histochemical observations.
作者信息
Persson L, Sima A
出版信息
Neurobiology. 1975 Jun;5(3):151-66.
The effect of pre- and postnatal undernutrition on the neuronal enzymatic maturation of the neocerebellar hemispheral lobules VI b, VI c and VII (according to Larsell 1952) was studied. Postnatally oxidative enzyme histochemistry (LDH, SDH, NADH, NADPH, G6PDH) revealed a delayed enzymatic development in the cerebellum between days 8 and 22, as an effect of pre- and postnatal undernutrition. In the Purkinje cell apical cone a delayed increase in enzyme activities could be seen at days 8 to 11 as well as a delayed decrease in Purkinje cell perikaryal enzyme activities at days 11 to 14 post-partum. The retarded enzymatic development seemed to parallel the retarded morphological development (cf. Sima & Persson 1975).
研究了产前和产后营养不良对新小脑半球小叶VI b、VI c和VII（根据Larsell 1952年的划分）神经元酶成熟的影响。出生后，通过氧化酶组织化学（乳酸脱氢酶、琥珀酸脱氢酶、烟酰胺腺嘌呤二核苷酸、烟酰胺腺嘌呤二核苷酸磷酸、葡萄糖-6-磷酸脱氢酶）发现，由于产前和产后营养不良，在出生后第8天至22天期间，小脑的酶发育延迟。在产后第8天至11天，浦肯野细胞顶锥的酶活性增加延迟，在产后第11天至14天，浦肯野细胞胞体酶活性下降延迟。酶发育迟缓似乎与形态发育迟缓平行（参见Sima和Persson 1975年的研究）。
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