Turska E, Lachowicz L, Koziołkiewicz W, Wasiak T
Gen Pharmacol. 1985;16(3):293-5. doi: 10.1016/0306-3623(85)90088-6.
The influence in vitro of analogues of Sp5-11 and SP6-11 substance P fragments on the activity of monoamine oxidase (MAO) in homogenates and crude mitochondrial fractions of rat brain was examined. The rat brain was divided into: I--cerebral cortex, II--hippocampus, III--midbrain, IV--thalamus with hypothalamus, V--cerebellum and VI--medulla oblongata. The obtained results proved that the analogues of SP fragments inhibit selectively the activity of the enzyme in the homogenates of cerebral cortex, hippocampus, midbrain and cerebellum. In the crude mitochondrial fractions the applied analogues of SP fragments caused a slight increase of the enzyme activity. The most significant changes in the activity of MAO were observed in hippocampus homogenate fraction.
研究了P物质片段Sp5 - 11和SP6 - 11类似物对大鼠脑匀浆和粗线粒体组分中单胺氧化酶（MAO）活性的体外影响。大鼠脑被分为：I - 大脑皮层，II - 海马体，III - 中脑，IV - 丘脑与下丘脑，V - 小脑，VI - 延髓。所得结果证明，SP片段类似物选择性抑制大脑皮层、海马体、中脑和小脑匀浆中该酶的活性。在粗线粒体组分中，所应用的SP片段类似物使该酶活性略有增加。MAO活性变化最显著的是在海马体匀浆组分中。
