Department of Conservative Dentistry, Division of Biomaterials and Engineering, Showa University School of Dentistry, Tokyo, Japan.
Department of Conservative Dentistry, Division of Aesthetic Dentistry and Clinical Cariology, Showa University School of Dentistry, Tokyo, Japan.
Nanomedicine. 2014 Apr;10(3):629-37. doi: 10.1016/j.nano.2013.09.007. Epub 2013 Oct 5.
The biomechanical stability of mineralized tissues at the interface between implant surface and bone tissue is of critical importance. Anodically oxidized titanium prepared in a chloride solution results in enhanced mineralization of adherent osteoblasts and has antimicrobial activity against oral microorganisms. We evaluated the nanomechanical properties and molecular structures of the in vitro mineralized tissues developing around anodically oxidized titanium surfaces with and without preparation in chloride solution. Anodically oxidized titanium surfaces showed superior osteogenic gene expressions than those of thermally oxidized and bare titanium surfaces. Preparation of anodically oxidized titanium in chloride enhanced the production of mineralized tissue around it. However, the mineralized tissue around anodically oxidized titanium prepared without chloride had increased mineral:matrix and cross-linking ratios, resulting in higher hardness and lower elasticity.
In this study anodically oxidized titanium was used to enhance the biomechanical stability of mineralized tissues at the implant surface -- bone tissue interface. The mineralized tissue around anodically oxidized titanium prepared without chloride had increased mineral:matrix and cross-linking ratios, resulting in higher hardness and lower elasticity.
矿化组织在植入物表面与骨组织交界处的生物力学稳定性至关重要。在氯化物溶液中阳极氧化的钛可增强附着成骨细胞的矿化,并具有抗口腔微生物的抗菌活性。我们评估了在有和没有氯化物预处理的情况下,围绕阳极氧化钛表面形成的体外矿化组织的纳米力学性能和分子结构。阳极氧化钛表面的成骨基因表达优于热氧化钛和纯钛表面。在氯化物中预处理阳极氧化钛可增强其周围矿化组织的生成。然而,在没有氯化物预处理的情况下形成的阳极氧化钛周围的矿化组织增加了矿物质/基质和交联的比例,导致硬度增加而弹性降低。
在这项研究中,阳极氧化钛被用于增强植入物表面-骨组织界面处矿化组织的生物力学稳定性。在没有氯化物预处理的情况下形成的阳极氧化钛周围的矿化组织增加了矿物质/基质和交联的比例,导致硬度增加而弹性降低。