Thränhardt H, Prager J, Fuchs D, Zintl F, Plenert W
Folia Haematol Int Mag Klin Morphol Blutforsch. 1985;112(2):285-92.
Mononuclear leukocytes from the peripheral blood and bone-marrow of children affected with aplastic anemia and leukemia were investigated for K-cell activity (antibody-dependent cellular cytotoxicity) and NK-cell activity before and after allogenous bone-marrow transplantation. 51Cr liberation test against murine Graffi erythroblast leukemic cells covered with xenoantibodies and K-562 cells were used for identification. Strongly lowered NK- and K-cell activities could be found in aplastic anemia prior to bone-marrow transplantation. However, NK-cell activity was only lowered significantly in leukemic patients with indication of bone-marrow transplantation. K-cell and NK-cell activities normalised after bone-marrow transplantation. K-cell and NK-cell activities could be observed to be reconstituted very early after bone-marrow transplantation.
对再生障碍性贫血和白血病患儿外周血及骨髓中的单核白细胞在同种异体骨髓移植前后进行了K细胞活性（抗体依赖性细胞毒性）和NK细胞活性研究。采用针对覆盖异种抗体的鼠Graffi成红细胞白血病细胞和K-562细胞的51Cr释放试验进行鉴定。在骨髓移植前的再生障碍性贫血患者中可发现NK细胞和K细胞活性显著降低。然而，仅在有骨髓移植指征的白血病患者中NK细胞活性显著降低。骨髓移植后K细胞和NK细胞活性恢复正常。在骨髓移植后很早就能观察到K细胞和NK细胞活性得到重建。
