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基质型药物递送系统的内在释放速率。

Intrinsic release rate from matrix-type drug delivery systems.

作者信息

Tojo K

出版信息

J Pharm Sci. 1985 Jun;74(6):685-7. doi: 10.1002/jps.2600740622.

DOI:10.1002/jps.2600740622
PMID:2410591
Abstract

A simple method was presented for evaluation of the intrinsic release rate from a matrix-type drug delivery system. The effect of the hydrodynamic diffusion boundary layer on the rate of drug release was corrected to obtain the release profile without any diffusion boundary layer effect. The experimental release data was logically explained in terms of the intrinsic rate of release evaluated from the present method.

摘要

提出了一种评估基质型药物递送系统内在释放速率的简单方法。校正了流体动力学扩散边界层对药物释放速率的影响，以获得无任何扩散边界层效应的释放曲线。根据用本方法评估的内在释放速率，对实验释放数据进行了合理的解释。

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