Conner J D, Detwiler P B, Sarthy P V
J Physiol. 1985 May;362:79-92. doi: 10.1113/jphysiol.1985.sp015664.
The ionic and electrophysiological properties of Müller cells, the principal glial element of the vertebrate retina, were investigated. The membrane potential of enzymatically dissociated and in situ Müller cells was about -80 mV and depended on external K+ concentration in a manner that was described by the Goldman-Hodgkin-Katz equation with a Na+-K+ permeability ratio of 0.037. The current-voltage relation showed marked inward rectification, with the input resistance at the resting potential being about 30 M omega for dissociated cells and about 3 M omega for in situ cells. In situ Müller cells were found to be electrically coupled to each other which could explain their lower resistance. We conclude that Müller cells are similar to other types of glia. In spite of a finite Na+ permeability their membrane potential is determined mainly by K+, they are electrically inexcitable and form an electrically coupled network in the retina.
对脊椎动物视网膜主要神经胶质成分——穆勒细胞的离子和电生理特性进行了研究。酶解分离的和原位的穆勒细胞膜电位约为-80mV，其依赖于外部K+浓度，这种方式可用戈德曼-霍奇金- Katz方程来描述，钠钾通透率为0.037。电流-电压关系显示出明显的内向整流，解离细胞在静息电位时的输入电阻约为30MΩ，原位细胞约为3MΩ。发现原位穆勒细胞彼此电耦合，这可以解释它们较低的电阻。我们得出结论，穆勒细胞与其他类型的神经胶质细胞相似。尽管有一定的Na+通透性，但其膜电位主要由K+决定，它们不能被电激发，且在视网膜中形成电耦合网络。
