新型癌蛋白 EPS8：癌症治疗的新靶点。

Novel oncoprotein EPS8: a new target for anticancer therapy.

机构信息

Department of Hematology, Zhujiang Hospital, Southern Medical University, 510282 Guangzhou, China.

出版信息

Future Oncol. 2013 Oct;9(10):1587-94. doi: 10.2217/fon.13.104.

DOI:10.2217/fon.13.104

Abstract

EPS8 was first identified as a tyrosine kinase substrate, that plays a role in EGFR-mediated mitogenic signaling. Recent research has shown that EPS8 is overexpressed in most types of cancer, for example breast cancer, colon cancer, cervical cancer and even hematologic malignancies. EPS8 is involved in many signaling pathways related to tumorigenesis, proliferation, migration and metastasis, and is a biomarker for poor prognosis of cancer patients. This review aims to provide a comprehensive picture of the role of EPS8 in cellular processes and its significance to tumorigenesis. Furthermore, this review focuses on the potential role of EPS8 as a therapeutic cancer target.

摘要

EPS8 最初被鉴定为一种酪氨酸激酶底物，在 EGFR 介导的有丝分裂信号中发挥作用。最近的研究表明，EPS8 在大多数类型的癌症中过度表达，例如乳腺癌、结肠癌、宫颈癌，甚至血液恶性肿瘤。EPS8 参与与肿瘤发生、增殖、迁移和转移相关的许多信号通路，是癌症患者预后不良的生物标志物。本文综述旨在全面阐述 EPS8 在细胞过程中的作用及其对肿瘤发生的意义。此外，本文还重点探讨了 EPS8 作为治疗性癌症靶点的潜在作用。