Meakin B J, Stevens J, Davies D J
J Pharm Pharmacol. 1978 Feb;30(2):75-80. doi: 10.1111/j.2042-7158.1978.tb13165.x.
The thermal (dark) degradation of promethazine hydrochloride in aqueous solution presents a complex kinetic picture. The process is oxygen dependent and is modified by EDTA. In citrate buffer, pH 4.0, ionic strength 0.5M, containing 0.1% EDTA, the thermal degradation at 90 degrees can be fitted to first order rate plots at drug concentrations up to 1.56 x 10.27 (0.5%) and to zero order rate plots at drug concentrations greater than 9.35 x 10.2M (3.0%). At intermediate concentrations no simple equation can describe the data. These effects have been correlated with the formation of drug micelles and the rate date have been interpreted on the basis of a first order monomer process and a half order micellar process occurring simultaneously.
盐酸异丙嗪在水溶液中的热（暗）降解呈现出复杂的动力学情况。该过程依赖于氧气，并受到乙二胺四乙酸（EDTA）的影响。在pH值为4.0、离子强度为0.5M且含有0.1%EDTA的柠檬酸盐缓冲液中，90℃下的热降解在药物浓度高达1.56×10⁻²⁷（0.5%）时可拟合为一级速率图，而在药物浓度大于9.35×10⁻²M（3.0%）时可拟合为零级速率图。在中间浓度时，没有简单的方程能够描述这些数据。这些效应与药物胶束的形成相关，并且速率数据是基于同时发生的一级单体过程和半级胶束过程来解释的。
