Bailey P T, Pradhan S N
Res Commun Chem Pathol Pharmacol. 1975 Aug;11(4):543-52.
Self-stimulation behavior in rats was facilitated by two adrenergic stimulants, amphetamine (0.5 or 1 mg/kg, intraperitoneal, i.p., or 100 mug, intracerebroventricular, i.c.v.) and cocaine (5 mg/kg, i.p.). Three alpha-adrenergic blockers (phenoxybenzamine, dibenamine, phentolamine) and a beta-adrenergic blocker (propranolol) decreased self-stimulation responding at 100 mug i.c.v. doses, but showed very little effect at small i.p. doses. Pretreatment with alpha- and beta-adrenergic blockers (i.c.v.) also decreased amphetamine-facilitated responding. The effects of amphetamine or cocaine (i.p.) were not significantly altered by these blockers at the doses used. The depressant effects of the alpha- and beta-adrenergic blockers on self-stimulation behavior appear to be nonspecific with respect to the type of adrenergic receptors.
两种肾上腺素能兴奋剂，即苯丙胺（0.5或1毫克/千克，腹腔注射，或100微克，脑室内注射）和可卡因（5毫克/千克，腹腔注射），可促进大鼠的自我刺激行为。三种α-肾上腺素能阻滞剂（酚苄明、二苄胺、酚妥拉明）和一种β-肾上腺素能阻滞剂（普萘洛尔）在脑室内注射100微克剂量时可降低自我刺激反应，但在腹腔注射小剂量时作用甚微。预先用α-和β-肾上腺素能阻滞剂（脑室内注射）也可降低苯丙胺促进的反应。在所用剂量下，这些阻滞剂对苯丙胺或可卡因（腹腔注射）的作用无明显改变。α-和β-肾上腺素能阻滞剂对自我刺激行为的抑制作用似乎与肾上腺素能受体类型无关。
