博来霉素消除多拷贝质粒R6K
Elimination of multicopy plasmid R6K by bleomycin.
作者信息
Attfield P V, Pinney R J
出版信息
Antimicrob Agents Chemother. 1985 Jun;27(6):985-8. doi: 10.1128/AAC.27.6.985.
Abstract
Bleomycin eliminated multicopy plasmid R6K from growing cells of Escherichia coli AB1157 but failed to cure either of the low-copy plasmids R1 or R46. Measurements of R6K-encoded beta-lactamase and of covalently closed plasmid DNA indicated that the drug causes a progressive reduction in plasmid copy number.
摘要
博来霉素可从生长的大肠杆菌AB1157细胞中消除多拷贝质粒R6K，但无法消除低拷贝质粒R1或R46中的任何一种。对R6K编码的β-内酰胺酶和共价闭合质粒DNA的测量表明，该药物会使质粒拷贝数逐渐减少。
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本文引用的文献
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Characterization of long patch excision repair of DNA in ultraviolet-irradiated Escherichia coli: an inducible function under rec-lex control.紫外线照射的大肠杆菌中DNA长片段切除修复的特性：rec-lex控制下的一种可诱导功能。
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Plasmid R46-mediated protection against bleomycin is poLA+-dependent.质粒R46介导的对博来霉素的抗性依赖于poLA+。
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The purification and properties of the -lactamase specified by the resistance factor R-1818 in Escherichia coli and Proteus mirabilis.大肠杆菌和奇异变形杆菌中由抗性因子R - 1818所指定的β - 内酰胺酶的纯化及特性
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Circular R-factor molecules controlling penicillinase synthesis, replicating in Escherichia coli under either relaxed or stringent control.控制青霉素酶合成的环状R因子分子，在松弛或严谨控制下于大肠杆菌中复制。
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