Pope Harrison G, Kanayama Gen, Athey Alison, Ryan Erin, Hudson James I, Baggish Aaron
Biological Psychiatry Laboratory, McLean Hospital, Belmont, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.
Am J Addict. 2014 Jul-Aug;23(4):371-7. doi: 10.1111/j.1521-0391.2013.12118.x. Epub 2013 Sep 20.
Although various surveys have tracked the prevalence of anabolic-androgenic steroid (AAS) use in American teenagers and young adults, no recent surveys have assessed the lifetime prevalence of AAS use in Americans overall. We therefore analyzed serial youth-survey data to derive estimates of the lifetime prevalence of AAS use in the current American general population.
We first determined the distribution of age of onset of AAS use, based on pooled data from nine studies. Using this distribution, we then developed equations to project the eventual lifetime prevalence of AAS use among young survey respondents, once they aged and completed the period of risk for initiating AAS. We similarly calculated the denominator of lifetimes of risk for AAS use in the total American population. We next applied these equations to four independent national youth datasets to derive current American general-population estimates for lifetime AAS use. Finally, using data from 10 pooled studies, we estimated the lifetime prevalence of AAS dependence among AAS users.
Age-of-onset studies consistently showed that AAS use begins later than most drugs, with only 22% of users (95% confidence interval: 19-25%) starting before age 20. Applying the age-of-onset findings to national youth datasets, we estimated that among Americans currently age 13-50 years, 2.9-4.0 million have used AAS. Within this group, roughly 1 million may have experienced AAS dependence.
Although subject to various limitations, our estimation techniques suggest a surprisinigly high prevalence of AAS use and dependence among Americans.
尽管多项调查追踪了美国青少年和青年中合成代谢雄激素类固醇(AAS)的使用流行情况,但近期尚无调查评估全体美国人中AAS使用的终生流行率。因此,我们分析了一系列青少年调查数据,以得出当前美国普通人群中AAS使用终生流行率的估计值。
我们首先根据9项研究的汇总数据确定了AAS使用开始年龄的分布。利用这一分布,我们随后建立了方程,以预测年轻调查对象在达到年龄并完成开始使用AAS的风险期后最终的AAS使用终生流行率。我们同样计算了美国总人口中AAS使用风险寿命的分母。接下来,我们将这些方程应用于4个独立的全国青少年数据集,以得出当前美国普通人群中AAS终生使用的估计值。最后,利用10项汇总研究的数据,我们估计了AAS使用者中AAS依赖的终生流行率。
开始年龄研究一致表明,AAS的使用开始时间比大多数药物晚,只有22%的使用者(95%置信区间:19 - 25%)在20岁之前开始使用。将开始年龄的研究结果应用于全国青少年数据集,我们估计,在目前年龄在13 - 50岁的美国人中,有290万至400万人使用过AAS。在这一群体中,约100万人可能经历过AAS依赖。
尽管存在各种局限性,但我们的估计技术表明,美国人中AAS的使用和依赖流行率高得惊人。