Danpanichkul Pojsakorn, Pang Yanfang, Sirimangklanurak Supapitch, Auttapracha Thanida, Pramotedham Thanawin, Pan Chun Wei, Koh Benjamin, Wong Zhen Yu, Saowapa Sakditad, Gunalan Shyna Zhuoying, Duangsonk Kwanjit, Kanitthamniyom Chanakarn, Kim Donghee, Wijarnpreecha Karn, Singal Amit G, Huang Daniel Q, Yang Ju Dong
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.
Cancers (Basel). 2025 Aug 25;17(17):2766. doi: 10.3390/cancers17172766.
The burden of early-onset cancer (cancer incidence <50 years) has increased globally. Early-onset cancer carries significant societal and economic consequences. We aim to provide updated estimates for incidence and mortality of early-onset cancer. We analyzed the Global Burden of Disease Study 2021 to describe the incidence, death, age-standardized incidence rate (ASIR), age-standardized death rate (ASDR) from early-onset cancer (i.e., cancer in people aged 15-49), and its changes from 2000 to 2021 (reflected as annual percent change [APC]), using Joinpoint regression analysis. In 2021, there were 3.16 million new cases and 989,650 deaths from early-onset cancer. From 2000 to 2021, the ASIR of early-onset cancer increased (APC: 0.40%, 95% CI 0.32 to 0.47%), with the highest increase observed in the Eastern Mediterranean region (APC: 1.63%, 95% CI 1.53 to 1.72%), whereas the ASDR decreased across most regions. The ASIR for early-onset cancer had a higher increase in females (APC: 0.62%, 95% CI 0.51 to 0.73%) than males (APC: 0.14%, 95% CI 0.04 to 0.23%). Breast cancer ( = 567,900) constituted the highest burden of incident cases, followed by non-melanoma skin ( = 507,810) and cervical cancers (n = 307,430). The highest increase in the ASIR was observed in non-melanoma skin cancer (APC:2.18%, 95% CI 1.85-2.51%), thyroid (APC: 1.70%, 95% CI 1.60 to 1.79%), and testicular (APC:1.37%, 95% CI 0.96 to 1.78%) cancers. The greatest increases in the ASDR were observed in peripheral nervous system cancer (APC: 0.97%, 95% CI 0.82 to 1.11%) and multiple myeloma (APC: 0.62%, 95% CI 0.51 to 0.72%). From 2000 to 2021, the age-adjusted incidence of early-onset cancer increased, with variation across regions and cancer types. Immediate measures are required at a global, regional, and national level to mitigate the burden of early-onset cancer.
全球范围内，早发性癌症（癌症发病年龄<50岁）的负担有所增加。早发性癌症会带来重大的社会和经济后果。我们旨在提供早发性癌症发病率和死亡率的最新估计。我们分析了《2021年全球疾病负担研究》，以描述早发性癌症（即15至49岁人群中的癌症）的发病率、死亡率、年龄标准化发病率（ASIR）、年龄标准化死亡率（ASDR）及其在2000年至2021年期间的变化（以年度百分比变化[APC]表示），采用Joinpoint回归分析。2021年，早发性癌症新增病例316万例，死亡989,650例。从2000年到2021年，早发性癌症的ASIR有所上升（APC：0.40%，95%CI为0.32至0.47%），其中东地中海地区上升幅度最大（APC：1.63%，95%CI为1.53至1.72%），而大多数地区的ASDR有所下降。早发性癌症的ASIR在女性中的上升幅度（APC：0.62%，95%CI为0.51至0.73%）高于男性（APC：0.14%，95%CI为0.04至0.23%）。乳腺癌（=567,900例）构成的发病病例负担最高，其次是非黑色素瘤皮肤癌（=507,810例）和宫颈癌（n=307,430例）。ASIR上升幅度最大的是在非黑色素瘤皮肤癌（APC：2.18%，95%CI为1.85 - 2.51%）、甲状腺癌（APC：1.70%，95%CI为1.60至1.79%）和睾丸癌（APC：1.37%，95%CI为0.96至1.78%）。ASDR上升幅度最大的是在周围神经系统癌症（APC：0.97%，95%CI为0.82至1.11%）和多发性骨髓瘤（APC：0.62%，95%CI为0.51至0.72%）。从2000年到2021年，早发性癌症的年龄调整发病率有所上升，各地区和癌症类型存在差异。需要在全球、区域和国家层面立即采取措施，以减轻早发性癌症的负担。
