Wildermuth Kerstin, Zabel Sonja, Rosychuk Rod A W
Department of Clinical Sciences, Colorado State University College of Veterinary Medicine and Biomedical Sciences, 300 West Drake, Fort Collins, CO 80523, USA; Tierdermatologie Dr. Wildermuth, Borsigstraße 7a, 65205, Wiesbaden, Germany.
Vet Dermatol. 2013 Dec;24(6):576-81, e137-8. doi: 10.1111/vde.12067. Epub 2013 Sep 20.
Various antihistamines have been used in the management of feline atopic dermatitis, with variable reported benefit. To date, there have been no randomized, double-blind, placebo-controlled, crossover clinical trials on the use of this drug class in cats.
HYPOTHESIS/OBJECTIVES: To evaluate the clinical efficacy of cetirizine hydrochloride for the control of pruritus and dermatitis in cats diagnosed with atopic dermatitis.
In this randomized, double-blind, placebo-controlled crossover clinical trial, 21 client-owned cats diagnosed with mild to moderate nonseasonal atopic dermatitis were randomly assigned to two groups. Cats in each group received either 1 mg/kg cetirizine hydrochloride or placebo once daily per os for 28 days followed by a 14 day wash-out period. Treatments were then crossed over, and cats received placebo or cetirizine hydrochloride for another 28 days. Owners marked a pruritus severity scale before inclusion in the study and weekly throughout the entire study period. Lesions were scored by the clinician using a Canine Atopic Dermatitis Extent and Severity Index (CADESI)-03 modified for the cat before enrolment and at day 28 of each treatment.
Nineteen cats completed the study. There were no statistically significant differences between treatment with cetirizine hydrochloride and placebo for modified CADESI-03 or pruritus scores.
This study suggests that cetirizine hydrochloride cannot be recommended for the management of feline atopic dermatitis.
多种抗组胺药已用于猫特应性皮炎的治疗，但其疗效报道不一。迄今为止，尚无关于此类药物在猫身上使用的随机、双盲、安慰剂对照、交叉临床试验。
假设/目的：评估盐酸西替利嗪对诊断为特应性皮炎的猫控制瘙痒和皮炎的临床疗效。
在这项随机、双盲、安慰剂对照的交叉临床试验中，21只确诊为轻度至中度非季节性特应性皮炎的家养猫被随机分为两组。每组猫每天口服1mg/kg盐酸西替利嗪或安慰剂，持续28天，随后有14天的洗脱期。然后进行交叉治疗，猫再接受28天的安慰剂或盐酸西替利嗪治疗。主人在纳入研究前和整个研究期间每周标记瘙痒严重程度量表。在入组前和每次治疗的第28天，临床医生使用针对猫改良的犬特应性皮炎范围和严重程度指数（CADESI-03）对病变进行评分。
19只猫完成了研究。盐酸西替利嗪治疗与安慰剂治疗在改良CADESI-03或瘙痒评分方面无统计学显著差异。
本研究表明，不推荐使用盐酸西替利嗪治疗猫特应性皮炎。
