Hishikawa R, Fukase M, Takenaka M, Fujita T
Biochem Biophys Res Commun. 1985 Jul 16;130(1):454-9. doi: 10.1016/0006-291x(85)90438-3.
Bay K 8644, a novel dihydropyridine, stimulates calcitonin secretion in a dose-dependent manner from a rat medullary thyroid carcinoma cell line, rMTC 6-23, and causes an increase in cytosolic free calcium concentration, as measured by quin-2. These effects are competitively inhibited by nifedipine, and completely abolished in the absence of extracellular calcium. These data suggest that calcium influx via voltage-dependent calcium channels plays a crucial role in the regulation of cytosolic free calcium concentration and calcitonin secretion.
新型二氢吡啶Bay K 8644能以剂量依赖方式刺激大鼠甲状腺髓样癌细胞系rMTC 6 - 23分泌降钙素，并导致胞质游离钙浓度升高，这是通过喹啉-2测定的。这些效应被硝苯地平竞争性抑制，且在无细胞外钙的情况下完全消失。这些数据表明，通过电压依赖性钙通道的钙内流在调节胞质游离钙浓度和降钙素分泌中起关键作用。
