钾离子浓度对2',5'-寡腺苷酸三聚体和四聚体三磷酸酯在兔网织红细胞裂解物中抑制蛋白质合成的影响。
Effects of K+ concentration on inhibition of protein synthesis by trimer and tetramer triphosphates of 2',5'-oligoadenylates in rabbit reticulocyte lysates.
作者信息
Wu J M, Konno S, Eslami B
出版信息
Biochem Biophys Res Commun. 1985 Jul 31;130(2):821-7. doi: 10.1016/0006-291x(85)90490-5.
The inhibition of protein synthesis by trimer or tetramer triphosphates of 2',5'-oligoadenylates (2-5A) in rabbit reticulocyte lysates is dependent on the concentration of K+ in the assay mixture. Based on studies using mRNA-dependent rabbit reticulocyte lysates and the degradation of [3H] polyadenylated mRNA, the greater inhibitory effects of trimer or tetramer triphosphates at the higher K+ is shown to be due to a more active 2-5A-dependent endoribonuclease (RNase L).
2',5'-寡腺苷酸（2-5A）的三聚体或四聚体三磷酸酯对兔网织红细胞裂解物中蛋白质合成的抑制作用取决于测定混合物中K+的浓度。基于使用依赖mRNA的兔网织红细胞裂解物以及[3H]聚腺苷酸化mRNA降解的研究，结果表明在较高K+浓度下三聚体或四聚体三磷酸酯具有更强的抑制作用是由于2-5A依赖性核糖核酸酶（RNase L）活性更高。
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