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孕酮对创伤性脑损伤的神经保护作用：血脑屏障中性粒细胞活化受抑制。

Neuroprotective effects of progesterone in traumatic brain injury: blunted in vivo neutrophil activation at the blood-brain barrier.

机构信息

Department of Surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery, Perelman School of Medicine at the University of Pennsylvania, The Trauma Center at Penn, 3400 Spruce Street, Maloney Building, 5th Floor, Philadelphia, PA 19104, USA.

出版信息

Am J Surg. 2013 Dec;206(6):840-5; discussion 845-6. doi: 10.1016/j.amjsurg.2013.07.016. Epub 2013 Oct 7.

DOI:10.1016/j.amjsurg.2013.07.016
PMID:24112683
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4149185/
Abstract

BACKGROUND

Progesterone (PRO) may confer a survival advantage in traumatic brain injury (TBI) by reducing cerebral edema. We hypothesized that PRO reduces edema by blocking polymorphonuclear (PMN) interactions with endothelium (EC) in the blood-brain barrier (BBB).

METHODS

CD1 mice received repeated PRO (16 mg/kg intraperitoneally) or vehicle (cyclodextrin) for 36 hours after TBI. Sham animals underwent craniotomy without TBI. The modified Neurological Severity Score graded neurologic recovery. A second craniotomy allowed in vivo observation of pial EC/PMN interactions and vascular macromolecule leakage. Wet/dry ratios assessed cerebral edema.

RESULTS

Compared with the vehicle, PRO reduced subjective cerebral swelling (2.9 ± .1 vs 1.2 ± .1, P < .001), PMN rolling (95 ± 1.8 vs 57 ± 2.0 cells/100 μm/min, P < .001), total EC/PMN adhesion (2.0 ± .4 vs .8 ± .1 PMN/100 μm, P < .01), and vascular permeability (51.8% ± 4.9% vs 27.1% ± 4.6%, P < .01). TBI groups had similar a Neurological Severity Score and cerebral wet/dry ratios (P > .05).

CONCLUSIONS

PRO reduces live pericontusional EC/PMN and BBB macromolecular leakage after TBI. Direct PRO effects on the microcirculation warrant further investigation.

摘要

背景

孕酮（PRO）通过减少脑水肿可能在创伤性脑损伤（TBI）中提供生存优势。我们假设 PRO 通过阻断多形核（PMN）与血脑屏障（BBB）内皮细胞（EC）的相互作用来减少水肿。

方法

CD1 小鼠在 TBI 后接受重复 PRO（16 mg/kg 腹腔内）或载体（环糊精）治疗 36 小时。假手术动物接受颅骨切开术而不进行 TBI。改良神经严重程度评分对神经恢复进行分级。第二次颅骨切开术允许在体内观察脑膜 EC/PMN 相互作用和血管大分子渗漏。干湿比评估脑水肿。

结果

与载体相比，PRO 减少了主观脑肿胀（2.9 ±.1 对 1.2 ±.1，P <.001）、PMN 滚动（95 ± 1.8 对 57 ± 2.0 细胞/100 μm/min，P <.001）、总 EC/PMN 粘附（2.0 ±.4 对.8 ±.1 PMN/100 μm，P <.01）和血管通透性（51.8% ± 4.9% 对 27.1% ± 4.6%，P <.01）。TBI 组的神经严重程度评分和脑干湿比相似（P >.05）。

结论

PRO 减少 TBI 后活的periocontusional EC/PMN 和 BBB 大分子渗漏。PRO 对微循环的直接作用值得进一步研究。

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本文引用的文献

1
Early management of severe traumatic brain injury.严重创伤性脑损伤的早期处理。
Lancet. 2012 Sep 22;380(9847):1088-98. doi: 10.1016/S0140-6736(12)60864-2.
2
Similar effects of hypertonic saline and mannitol on the inflammation of the blood-brain barrier microcirculation after brain injury in a mouse model.高渗盐水和甘露醇对脑损伤后小鼠模型血脑屏障微循环炎症的类似影响。
J Trauma Acute Care Surg. 2012 Aug;73(2):351-7; discussion 357. doi: 10.1097/TA.0b013e3182592f76.
3
A genomic storm in critically injured humans.危重症患者的基因组风暴。
二酰基甘油脂肪酶-β 基因敲除小鼠表现出创伤性脑损伤诱导的死亡率的性别依赖性降低，而对记忆或其他功能后果没有影响。
Cannabis Cannabinoid Res. 2021 Dec;6(6):508-521. doi: 10.1089/can.2020.0175. Epub 2021 Jun 17.
4
Post-traumatic brain injury antithrombin III recovers Morris water maze cognitive performance, improving cued and spatial learning.创伤性脑损伤后抗凝血酶 III 恢复 Morris 水迷宫认知表现，改善提示和空间学习。
J Trauma Acute Care Surg. 2021 Jul 1;91(1):108-113. doi: 10.1097/TA.0000000000003112.
5
Neuropharmacology in traumatic brain injury: from preclinical to clinical neuroprotection?创伤性脑损伤的神经药理学：从临床前神经保护到临床？
Fundam Clin Pharmacol. 2021 Jun;35(3):524-538. doi: 10.1111/fcp.12656. Epub 2021 Mar 13.
6
Maternal Progesterone Treatment Reduces Maternal Inflammation-Induced Fetal Brain Injury in a Mouse Model of Preterm Birth.母体孕酮治疗可减轻早产小鼠模型中母体炎症诱导的胎儿脑损伤。
Reprod Sci. 2021 Jan;28(1):166-176. doi: 10.1007/s43032-020-00272-w. Epub 2020 Aug 24.
7
Effect of progesterone administration on the prognosis of patients with severe traumatic brain injury: a meta-analysis of randomized clinical trials.孕激素给药对重度创伤性脑损伤患者预后的影响：一项随机临床试验的荟萃分析
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8
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9
A concomitant bone fracture delays cognitive recovery from traumatic brain injury.伴随性骨折会延迟创伤性脑损伤后的认知恢复。
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10
Sex-related responses after traumatic brain injury: Considerations for preclinical modeling.创伤性脑损伤后的性别相关反应：临床前模型的考虑因素。
Front Neuroendocrinol. 2018 Jul;50:52-66. doi: 10.1016/j.yfrne.2018.03.006. Epub 2018 May 18.
J Exp Med. 2011 Dec 19;208(13):2581-90. doi: 10.1084/jem.20111354. Epub 2011 Nov 21.
4
Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury.细胞因子与固有炎症在人类创伤性脑损伤发病机制中的作用。
Prog Neurobiol. 2011 Nov;95(3):352-72. doi: 10.1016/j.pneurobio.2011.09.003. Epub 2011 Sep 16.
5
Water, water, everywhere: sodium and water balance and the injured brain.到处都是水：钠和水的平衡与受伤的大脑。
Curr Opin Anaesthesiol. 2011 Apr;24(2):138-43. doi: 10.1097/ACO.0b013e32834458af.
6
Functional assessments in the rodent stroke model.啮齿动物中风模型中的功能评估。
Exp Transl Stroke Med. 2010 Jul 19;2(1):13. doi: 10.1186/2040-7378-2-13.
7
In vitro effect of the reproductive hormones on the oxidative burst activity of polymorphonuclear leucocytes from cows: a flow cytometric study.
Reprod Domest Anim. 2010 Oct;45(5):e40-5. doi: 10.1111/j.1439-0531.2009.01519.x.
8
Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial.急性重度创伤性脑损伤患者使用孕酮治疗的疗效改善：一项随机对照试验。
Crit Care. 2008;12(2):R61. doi: 10.1186/cc6887. Epub 2008 Apr 30.
9
Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion.皮质挫伤后，给予孕酮可调节大鼠脑内的Toll样受体/核因子-κB信号通路。
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10
Inhibitory effect of progesterone on inflammatory factors after experimental traumatic brain injury.孕酮对实验性创伤性脑损伤后炎症因子的抑制作用。
Biomed Environ Sci. 2007 Oct;20(5):432-8.