Department of Pediatrics, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, People's Republic of China.
Pediatr Neurol. 2013 Dec;49(6):397-400. doi: 10.1016/j.pediatrneurol.2013.08.022. Epub 2013 Oct 7.
The Transverse Myelitis Consortium Working Group has proposed new diagnostic criteria for acute transverse myelitis. The purpose of the present study is to evaluate the relations between clinical variables and functional prognosis using new criteria.
We reviewed 39 Chinese cases meeting the new criteria, recorded clinical epidemiological data, and followed activities of daily living measuring scale (Modified Barthel Index).
Thirty-nine children met new criteria for definite acute transverse myelitis in the past 14 years between 1995 and 2008. Mean follow-up time was 102.7 months. Conversion to multiple sclerosis occurred in two patients (5.1%). Those children with a short time to maximal deficits, long time of peak neurological impairment and initial time of treatment, increased protein levels of the cerebrospinal fluid, and secondary infection were more likely to have residual neurological deficits, resulting in lower qualities of life (P = 0.005, P = 0.003, P = 0.011, P = 0.0012, P = 0.000, respectively).
A short time to maximal deficits, long time of peak neurological impairment and initial time of treatment, increased protein levels of cerebrospinal fluid, and secondary infection played important roles in predicting poor prognosis.
急性横贯性脊髓炎协作组提出了新的急性横贯性脊髓炎诊断标准。本研究旨在使用新的标准评估临床变量与功能预后之间的关系。
我们回顾了 1995 年至 2008 年期间符合新诊断标准的 39 例中国病例，记录了临床流行病学数据，并采用日常生活活动量表（改良巴氏指数）进行随访。
在过去 14 年中，有 39 名儿童符合新的急性横贯性脊髓炎标准。平均随访时间为 102.7 个月。有 2 例（5.1%）转化为多发性硬化症。那些最短时间达到最大缺损、最高神经损伤时间和最初治疗时间、脑脊液蛋白水平升高以及继发感染的儿童更容易出现残留的神经缺损，导致生活质量较低（P=0.005、P=0.003、P=0.011、P=0.0012、P=0.000，分别）。
最短时间达到最大缺损、最高神经损伤时间和最初治疗时间、脑脊液蛋白水平升高以及继发感染在预测不良预后方面起着重要作用。
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