[改变钙转运的物质对培养心肌细胞收缩性的影响]
[Effect of substances modifying calcium movement on the contractility of cultured cardiac cells].
作者信息
Auclair M C, Vernimmen C, Lechat P
出版信息
C R Seances Soc Biol Fil. 1985;179(1):74-7.
PMID:2411367
Abstract
Cultured cardiac cells from newborn rats were found to be sensitive to the positive or negative inotropic effect of agents capable of interfering with calcium movements. Calcium entry blockers were found specially potent, since diltiazem and nifedipine were still active at concentration of 1 X 10(-9) M. Such a bioassay system seems therefore convenient to compare the relative potency of drugs belonging to this pharmacological class.
摘要
新生大鼠的培养心肌细胞被发现对能够干扰钙运动的药物的正性或负性肌力作用敏感。钙通道阻滞剂被发现特别有效，因为地尔硫卓和硝苯地平在1×10⁻⁹ M的浓度下仍有活性。因此，这样一种生物测定系统似乎便于比较属于这一药理学类别的药物的相对效力。
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