Jacobson R C, Chapman C R, Gerlach R
Electroencephalogr Clin Neurophysiol. 1985 Sep;62(5):352-63. doi: 10.1016/0168-5597(85)90044-9.
The inter-relationship between stimulus intensity and inter-stimulus interval (ISI) on pain-related evoked vertex potentials was studied. Sixteen subjects were tested with 4 stimulus intensities at 4 different ISIs forming 16 averaged event-related potentials for each subject. Data were analyzed in 2 ways: first by multiple regression analysis of peak-to-peak amplitudes and secondly by single-trial analysis for each subject based on a linear model employing principal component loadings as basis functions, from which were derived separate time-dependent functions describing the contributions of intensity and ISI. Peak-to-peak amplitudes of the averaged waves increased with increases in either intensity of ISI. There were no significant interactions. However, single-trial analysis revealed subtle, but consistent, differences in the peak latencies between stimulus and ISI components, suggesting that the components arise from distinct sources.
研究了刺激强度与刺激间隔（ISI）对疼痛相关诱发顶点电位的相互关系。16名受试者在4种不同的ISI下接受4种刺激强度的测试，为每个受试者形成16个平均事件相关电位。数据采用两种方式进行分析：一是对峰峰值振幅进行多元回归分析，二是基于以主成分负荷为基函数的线性模型对每个受试者进行单次试验分析，从中得出描述强度和ISI贡献的独立时间相关函数。平均波的峰峰值振幅随ISI强度的增加而增加。没有显著的相互作用。然而，单次试验分析显示刺激成分和ISI成分之间的峰值潜伏期存在细微但一致的差异，表明这些成分来自不同的来源。
