Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore).
Angew Chem Int Ed Engl. 2013 Nov 18;52(47):12354-8. doi: 10.1002/anie.201305023. Epub 2013 Oct 2.
Many hands make light work: In an organocatalytic asymmetric sulfonation of enones, the activation of a sulfonyl imine by an N-heterocyclic carbene (NHC) catalyst led to the release of a sulfinic anion, which underwent nucleophilic addition to the enone. The enantioselectivity of the process was controlled by a chiral thiourea/amine co-catalyst through anion recognition and hydrogen-bonding interactions. Tol=p-tolyl.
在烯酮的有机催化不对称磺化反应中，亚磺酰亚胺通过 N-杂环卡宾（NHC）催化剂的活化，释放出亚磺酸阴离子，该阴离子对烯酮进行亲核加成。该过程的对映选择性通过手性硫脲/胺共催化剂通过阴离子识别和氢键相互作用进行控制。Tol=p-甲苯基。
