Swinbourne F, Kulendra E, Smith K, Leo C, Ter Haar G
Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hertfordshire.
Department of Pathology and Infectious Diseases, The Royal Veterinary College, Hertfordshire.
J Small Anim Pract. 2014 Feb;55(2):121-4. doi: 10.1111/jsap.12140. Epub 2013 Oct 9.
A 4·5-year-old, female neutered Leonberger was presented with a 2-month history of sneezing, nasal discharge and epistaxis. A presumptive diagnosis of nasal aspergillosis was made based on a suspected (fungal) granuloma on rhinoscopic examination and fungal hyphae on cytological examination. A poor response to targeted therapy was observed and computed tomography 16 months after initial presentation revealed a progressive, locally invasive mass lesion. Histopathological and immunohistochemical analysis of deep surgical biopsies revealed a spindle cell population and a plasma cell rich inflammatory infiltrate, with diffuse expression of vimentin, supporting a diagnosis of inflammatory myofibroblastic tumour. Complete resolution of the nasal discharge and reduced sneezing frequency was reported 9 months post-surgical debridement via rhinotomy. To the authors' knowledge, this is the first report of IMT in the nasal cavity of a dog. IMT should be considered when presented with a nasal mass lesion, particularly if histopathological features and clinical course are inconsistent.
一只4.5岁已绝育的雌性圣伯纳犬出现了为期2个月的打喷嚏、流鼻涕和鼻出血症状。根据鼻镜检查发现疑似（真菌）肉芽肿以及细胞学检查发现真菌菌丝，初步诊断为鼻曲霉菌病。观察到靶向治疗效果不佳，初次就诊16个月后的计算机断层扫描显示有一个进行性、局部侵袭性肿块病变。深部手术活检的组织病理学和免疫组织化学分析显示有梭形细胞群和富含浆细胞的炎性浸润，波形蛋白呈弥漫性表达，支持炎性肌纤维母细胞瘤的诊断。经鼻切开术进行手术清创9个月后，报告称鼻涕完全消失，打喷嚏频率降低。据作者所知，这是犬鼻腔炎性肌纤维母细胞瘤的首例报告。当出现鼻腔肿块病变时，尤其是组织病理学特征和临床病程不一致时，应考虑炎性肌纤维母细胞瘤。
