Department of Paediatrics, Stavanger University Hospital, Stavanger, Norway.
Acta Paediatr. 2014 Jan;103(1):86-92. doi: 10.1111/apa.12432. Epub 2013 Nov 11.
To assess whether inflammatory markers measured in urine and blood during acute bronchiolitis in infancy were associated with asthma, lung function, bronchial hyper-responsiveness (BHR) and atopy at 11 years of age.
We included 105 children hospitalised for bronchiolitis during their first year of life. At hospitalisation, urinary (U-) eosinophil protein X, U-leukotriene E4 , U-prostaglandin 9α, 11β-PGF2 and blood eosinophil counts were measured. Ninety-five children (90%) were available for follow-up at 11 years of age.
At follow-up, higher blood eosinophil counts obtained during bronchiolitis were observed in the group with asthma than in the group without asthma (median 0.27 versus 0.09 × 10(9) /L, respectively, p = 0.048). By regression analyses, blood eosinophil counts during the acute bronchiolitis were positively associated with BHR (p = 0.006) and negatively associated with forced expiratory volume in first second (p = 0.025) at 11 years of age. None of the other inflammatory markers were associated with asthma, lung function, BHR or atopy at 11 years of age.
Eosinophil inflammation during bronchiolitis may have a long-term impact on lung function and airway responsiveness. The associations could be related to virus-host interactions during bronchiolitis or to predisposed children.
评估婴儿期急性细支气管炎时尿液和血液中炎症标志物与 11 岁时哮喘、肺功能、支气管高反应性（BHR）和特应性的关系。
我们纳入了 105 例因细支气管炎在生命的第一年住院的儿童。在住院期间，测量了尿（U）嗜酸性粒细胞蛋白 X、U-白三烯 E4、U-前列腺素 9α、11β-PGF2 和血嗜酸性粒细胞计数。95 例儿童（90%）在 11 岁时可进行随访。
在随访中，哮喘组的急性细支气管炎期间血嗜酸性粒细胞计数高于无哮喘组（中位数分别为 0.27 和 0.09×10(9)/L，p=0.048）。通过回归分析，急性细支气管炎期间的血嗜酸性粒细胞计数与 BHR 呈正相关（p=0.006），与第 1 秒用力呼气量呈负相关（p=0.025）。其他炎症标志物与 11 岁时的哮喘、肺功能、BHR 或特应性均无关。
细支气管炎期间的嗜酸性粒细胞炎症可能对肺功能和气道反应性产生长期影响。这些关联可能与细支气管炎期间的病毒-宿主相互作用或易感性儿童有关。
