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[人绒毛膜促性腺激素治疗后犬实验性单侧隐睾症的组织化学研究(作者译)]

[Histochemical investigations in the experimental unilateral cryptorchism of the dog after HCG-treatment (author's transl)].

作者信息

Weissbach L, Heinemann I, Goslar H G

出版信息

Acta Histochem. 1975;52(1):62-70.

PMID:241190
Abstract

The behavior of various enzymes in the orthotopic and dystopic dog testis was examined under the conditions of experimental unilateral cryptorchism after HCG-treatment over a period of 3 months. The following findings could be obtained: 1. Under the HCG-application the orthotopic impuberal testis there was a change of behavior of the enzyme in the tubuli and Leydig-cells in comparison with test animals. A loss of LDH of the epithelium of the tubuli can be avoided through HCG-treatment. 2. In the dystopic testis of the impuberal animal, HCG cannot avoid this loss of LDH in the epithelium of the tubuli. In the Leydig cell complexes the Glucose-6-Phosphate-Dehydrogenase shows an increase of activity. 3. In the Leydig cell complexes of the impuberal testis an apparent loss of LDH is noticeable in the epithelium of the tubuli, while the non-specific esterase, SDH and the Glucose-6-Phosphate Dehydrogenase increases in activity. The activity of the Leydig cell complexes shows the expected stimulation. The present results prove that under a large dose of HCG-treatment can lead to different changes in the enzymes of the orthotopic testis of dogs.

摘要

在对狗进行为期3个月的人绒毛膜促性腺激素(HCG)治疗后的实验性单侧隐睾症条件下,研究了各种酶在原位和异位狗睾丸中的行为。可获得以下结果:1. 在应用HCG时,与对照动物相比,原位未成熟睾丸的曲细精管和睾丸间质细胞中的酶行为发生了变化。通过HCG治疗可避免曲细精管上皮乳酸脱氢酶(LDH)的损失。2. 在未成熟动物的异位睾丸中,HCG不能避免曲细精管上皮中LDH的这种损失。在睾丸间质细胞复合体中,葡萄糖-6-磷酸脱氢酶(Glucose-6-Phosphate-Dehydrogenase)的活性增加。3. 在未成熟睾丸的睾丸间质细胞复合体中,曲细精管上皮中明显可见LDH的损失,而非特异性酯酶、琥珀酸脱氢酶(SDH)和葡萄糖-6-磷酸脱氢酶的活性增加。睾丸间质细胞复合体的活性显示出预期的刺激作用。目前的结果证明,大剂量HCG治疗可导致狗原位睾丸中的酶发生不同变化。

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