Erban L, Hanzlícek L
Act Nerv Super (Praha). 1975 Mar;17(1):20-4.
The authors follow up on their previous studies of morphological changes in the properties of white blood cells represented by the oxygen pycnotic index Qp in patients with the schizophrenic syndrome. Several years of research made it obvious to them that this index remains generally unaffected by drugs administered during the treatment although the patient does show a pronounced clinical change. They decided to substitute the offer of oxygen by adding a supply of cytochrome c and NADP, i.e. by substances that give a boost to the oxidoreduction processes within the cell. They found the pycnotic quotient, based on cytochrome c, and - to an even greater degree - the NADP-based quotient to be more responsive to differences in the seriousness of the disease than the oxygen quotient.
作者对他们之前关于精神分裂症综合征患者中以氧固缩指数Qp表示的白细胞特性形态变化的研究进行了跟进。数年的研究使他们清楚地认识到，尽管患者确实出现了明显的临床变化，但该指数通常不受治疗期间所服药物的影响。他们决定通过添加细胞色素c和NADP的供应来替代氧供应，即通过促进细胞内氧化还原过程的物质。他们发现，基于细胞色素c的固缩商数，以及在更大程度上基于NADP的商数，比氧商数对疾病严重程度的差异更敏感。
