Department of Emergency Medicine, Section of Medical Toxicology, University of Southern California, Los Angeles, CA, USA.
Department of Emergency Medicine, University of Southern California, Los Angeles, CA, USA.
Am J Emerg Med. 2014 Jan;32(1):71-4. doi: 10.1016/j.ajem.2013.08.063. Epub 2013 Oct 8.
Clopidogrel is an adenosine diphosphate receptor antagonist. The risk of intracranial hemorrhage following minor head trauma in patients with pre-injury use of clopidogrel has not been fully determined.
This case-controlled study examined the effects of pre-injury use of clopidogrel in adult (age 14 years and older) patients with minor head trauma.
During the study period, 1660 patients head computed tomography scans were performed in the emergency department, of which 658 met inclusion criteria. Intracranial hemorrhage was noted in 30% of patients on clopidogrel, compared with 2.2% of those patients without pre-injury use of clopidogrel. After performing a logistic regression analysis for confounders, the pre-injury use of clopidogrel was significantly associated with intracranial hemorrhage in this study population (OR 16.7; 95% CI 1.71-162.7).
The use of clopidogrel is associated with a significantly increased risk of developing intracranial hemorrhage following minor trauma.
氯吡格雷是一种二磷酸腺苷受体拮抗剂。有研究表明，在轻微头部创伤的患者中，既往使用氯吡格雷会增加颅内出血的风险，但目前尚未完全确定。
本病例对照研究旨在探讨在轻微头部创伤的成年（14 岁及以上）患者中，既往使用氯吡格雷对颅内出血的影响。
在研究期间，共有 1660 名患者在急诊科接受了头部计算机断层扫描，其中 658 名符合纳入标准。在使用氯吡格雷的患者中，30%的患者发生颅内出血，而未使用氯吡格雷的患者中这一比例为 2.2%。对混杂因素进行逻辑回归分析后，本研究人群中既往使用氯吡格雷与颅内出血显著相关（OR 16.7；95%CI 1.71-162.7）。
在轻微创伤后，使用氯吡格雷会显著增加颅内出血的风险。
