Hanai S, Shimosato Y, Watanabe S, Sato Y, Kishi K, Kakizoe T, Matsumoto K
Gan No Rinsho. 1985 Jun;31(7):839-46.
Ten resected bladder cancers were studied immunohistochemically using monoclonal antibodies to clarify the subsets of infiltrating lymphocytes and histiocytes. Leu 4+ T-lymphocytes infiltrated diffusely both in the stroma and the submucosal tissue, but Bl+ B-lymphocytes usually formed follicle-like clusters in the submucosal tissue. The number of Leu 4+, Leu 3 a+ helper/inducer T-lymphocytes was considerably more than that of Leu 4+, Leu 2 a+ suppressor/cytotoxic T-lymphocytes. Leu 7+ natural killer cells were sparsely present in the submucosal tissue, and there was no suggestion of any significant contact with cancer cells. OKT9+ OKM1+ macrophages were prominent in the inflammatory lesions, but OKT6+ T-zone histiocytes were characteristically present among the cancer cells. Patients with dense infiltration of OKT6+ T-zone histiocytes were expected to have a good prognosis.
使用单克隆抗体对10例切除的膀胱癌进行免疫组织化学研究，以明确浸润淋巴细胞和组织细胞的亚群。Leu 4 + T淋巴细胞在基质和黏膜下组织中均呈弥漫性浸润，但B1 + B淋巴细胞通常在黏膜下组织中形成滤泡样簇。Leu 4 +、Leu 3 a +辅助/诱导性T淋巴细胞的数量明显多于Leu 4 +、Leu 2 a +抑制/细胞毒性T淋巴细胞。Leu 7 +自然杀伤细胞稀疏地存在于黏膜下组织中，未显示出与癌细胞有任何明显接触。OKT9 + OKM1 +巨噬细胞在炎性病变中很突出，但OKT6 + T区组织细胞特异地存在于癌细胞之间。预计OKT6 + T区组织细胞密集浸润的患者预后良好。
