van Zwieten P A, Timmermans P B
J Cardiovasc Pharmacol. 1985;7 Suppl 4:S11-7. doi: 10.1097/00005344-198507004-00003.
Calcium entry blockers or calcium antagonists have been recognized as useful antihypertensive drugs, although their definite position in the management of hypertensive disease remains to be established. The present survey deals with the pharmacological basis of their antihypertensive action, side effects, contraindications, and interactions with other drugs. The antihypertensive effect of the various calcium entry blockers is fully explained by arteriolar dilatation, thus leading to a reduction in total peripheral resistance. At a cellular level this effect is assumed to be induced by the selective inhibition of the slow inward current that is carried by calcium ion fluxes. Furthermore, the interaction with vascular postsynaptic alpha 2-adrenoceptor-mediated vasoconstriction may also contribute to vasodilatation.
钙通道阻滞剂或钙拮抗剂已被公认为有效的抗高血压药物，尽管它们在高血压疾病治疗中的明确地位仍有待确立。本综述探讨了它们抗高血压作用的药理学基础、副作用、禁忌证以及与其他药物的相互作用。各种钙通道阻滞剂的抗高血压作用完全是由小动脉扩张所解释的，从而导致总外周阻力降低。在细胞水平上，这种作用被认为是由对钙离子内流所携带的缓慢内向电流的选择性抑制所诱导的。此外，与血管突触后α2-肾上腺素能受体介导的血管收缩的相互作用也可能有助于血管舒张。
