Hägerstrand I
Acta Pathol Microbiol Scand A. 1975 Sep;83(5):527-33. doi: 10.1111/j.1699-0463.1975.tb00164.x.
56 human liver biopsy specimens with insignificant or no histological changes, but with abnormally strong canalicular alkaline phosphatase activity, were studied histochemically for other enzyme changes. In comparison with normal specimens, more extensive and increased canalicular activity of gamma-glutamyl transferase, and increase of canalicular leucine aminopeptidase, was found, while the sinusoidal activity of the latter enzyme was decreased. Staining for adenosine triphosphatase regularly desclosed the normal pattern of sinusoidal and canalicular activity. The lysosomal enzymes, acid phosphatase and beta-glucuronidase, stained more intensely than ordinarily, while the reactions for enzymes present in the cytosol (lactic dehydrogenase), in the mitochondria (succinic dehydrogenase, imonoamine oxidase) and in the endoplasmic reticulum (glucose-6-phosphatase) were normal.
对56份肝活检标本进行了组织化学研究，以观察其他酶的变化。这些标本组织学变化不明显或无变化，但小管碱性磷酸酶活性异常增强。与正常标本相比，发现γ-谷氨酰转移酶的小管活性更广泛且增强，小管亮氨酸氨肽酶增加，而后一种酶的窦状隙活性降低。三磷酸腺苷酶染色显示窦状隙和小管活性的正常模式。溶酶体酶、酸性磷酸酶和β-葡萄糖醛酸酶的染色比通常更强烈，而细胞溶质（乳酸脱氢酶）、线粒体（琥珀酸脱氢酶、单胺氧化酶）和内质网（葡萄糖-6-磷酸酶）中存在的酶的反应正常。
