Division of Urology, Ospedale Gradenigo, Corso Regina Margherita 8, 10153, Torino, Italy.
Anticancer Res. 2013 Oct;33(10):4657-62.
To evaluate the relationship between Prostate cancer gene 3 (PCA3) score and prostate cancer as assessed by Gleason Score (GS) and pathological stage in a series of Italian patients, with elevated Prostate specific antigen (PSA) undergoing radical prostatectomy (RP).
A total of 222 patients underwent RP for clinically localized prostate cancer; total PSA, free-PSA (%fPSA) and PCA3 score were collected and the possible associations among PCA3 and histological grade/pathological stage at biopsy and RP were investigated.
Median PCA3 scores by GS at radical prostatectomy were 51 vs. 67 (GS <7 vs. GS ≥ 7, p=0.007), while scores at the biopsy were 56 vs. 67 (GS <7 vs. GS ≥ 7, p=0.007), and in pT2 vs. pT3 patients they were 54 vs. 80 (p=0.001). Positive digital rectal examination (DRE) (odds ratio (OR)=5.47, p=0.026), pT3 pathological stage (OR=3.68, p=0.006) and PCA3 ≥ 35 (OR=2.04, p=0.030) were the main risk factors for the presence of an aggressive disease (GS ≥ 7 at RP).
PCA3 score could play an interesting role in predicting significant disease: positive DRE (OR=5.47, p=0.026), pT3 pathological stage (OR=3.68, p=0.006) and PCA3 ≥ 35 (OR=2.04, p=0.030) were the main independent risk factors for GS ≥ 7 at RP.
评估前列腺癌基因 3（PCA3）评分与前列腺癌之间的关系，该研究对一系列意大利患者进行了评估，这些患者的前列腺特异性抗原（PSA）水平升高，接受了根治性前列腺切除术（RP）。
共有 222 例患者因临床局限性前列腺癌接受 RP；收集了总 PSA、游离 PSA（%fPSA）和 PCA3 评分，并研究了 PCA3 与活检和 RP 时的组织学分级/病理分期之间的可能关联。
RP 时按 GS 中位数的 PCA3 评分分别为 51 与 67（GS <7 与 GS ≥ 7，p=0.007），而在活检时分别为 56 与 67（GS <7 与 GS ≥ 7，p=0.007），在 pT2 与 pT3 患者中分别为 54 与 80（p=0.001）。阳性直肠指检（DRE）（优势比（OR）=5.47，p=0.026）、pT3 病理分期（OR=3.68，p=0.006）和 PCA3≥35（OR=2.04，p=0.030）是 RP 时存在侵袭性疾病的主要危险因素。
PCA3 评分可能在预测显著疾病方面发挥作用：阳性 DRE（OR=5.47，p=0.026）、pT3 病理分期（OR=3.68，p=0.006）和 PCA3≥35（OR=2.04，p=0.030）是 RP 时 GS≥7 的主要独立危险因素。
