INSERM U894, Université Paris Descartes, Service de Neurologie, Hôpital Sainte-Anne, Paris, France; CNRS UMR 7287, Aix-Marseille Université, Marseille, France.
Mov Disord. 2014 Jan;29(1):130-4. doi: 10.1002/mds.25690. Epub 2013 Oct 10.
Abnormal cortical processing of sensory inputs has been found bilaterally in writer's cramp (WC). This study tested the hypothesis that patients with WC have an impaired ability to adjust grip forces according to visual and somatosensory cues in both hands.
A unimanual visuomotor force-tracking task and a bimanual sense of effort force-matching task were performed by WC patients and healthy controls.
In visuomotor tracking, WC patients showed increased error, greater variability, and longer release duration than controls. In the force-matching task, patients underestimated, whereas controls overestimated, the force applied in the other hand. Visuomotor tracking and force matching were equally impaired in both the symptomatic and nonsymptomatic hand in WC patients.
This study provides evidence of bilaterally impaired grip-force control in WC, when using visual or sense of effort cues. This suggests a generalized subclinical deficit in sensorimotor integration in WC.
在书写痉挛（WC）患者中双侧出现了感觉输入的皮质处理异常。本研究检验了如下假设，即 WC 患者在根据双手的视觉和本体感觉线索调整握力方面存在能力受损。
使用单手持物视觉运动力跟踪任务和双手用力感匹配任务对 WC 患者和健康对照组进行测试。
在视觉运动跟踪中，WC 患者的误差、变异性和释放时间均大于对照组。在力量匹配任务中，患者低估了另一只手施加的力，而对照组则高估了。在 WC 患者中，无论是症状手还是非症状手，视觉运动跟踪和力量匹配均受到同等程度的损害。
本研究提供了在使用视觉或用力感觉线索时，WC 患者双侧握力控制受损的证据。这表明 WC 存在一种广泛的亚临床感觉运动整合缺陷。
