因子 IX 活性升高与动脉和静脉血栓栓塞事件的比值比增加相关。
Elevated factor IX activity is associated with an increased odds ratio for both arterial and venous thrombotic events.
机构信息
ARUP Laboratories, 500 Chipeta Way, Mail Stop 115-G04, Salt Lake City, UT 84108;
出版信息
Am J Clin Pathol. 2013 Nov;140(5):680-5. doi: 10.1309/AJCPAGOR4Q2IIKUG.
OBJECTIVES
Elevations of factor IX (FIX) are thought to contribute to thrombotic risk, but this has not been well characterized. We retrospectively sought to determine whether elevated FIX levels are a risk factor for thrombosis in 81 adult subjects younger than 65 years (mean, 47 years) who were referred for evaluation of a hypercoagulable state.
METHODS
Patients were classified by arterial transient ischemic attack/stroke (TIA/stroke, n = 62) or venous thromboembolism (VTE, n = 19) events. FIX activity testing was performed on all 81 subjects and a reference group of 40 healthy individuals.
RESULTS
Thirteen (21%) of 62 subjects with TIA/stroke and 5 (26%) of 19 subjects with VTE had elevated FIX activity. Odds ratios for TIA/stroke and VTE in subjects with elevated FIX activity were 3.7 (95% confidence interval [CI], 0.76-17.65) and 6.8 (95% CI, 1.18-39.07), respectively.
CONCLUSIONS
Our findings suggest an association between elevated FIX levels and both arterial and venous thrombotic events.
目的
因子 IX（FIX）水平升高被认为会增加血栓形成风险，但这一现象尚未得到充分阐明。我们回顾性研究旨在确定 81 名年龄均小于 65 岁（平均年龄 47 岁）的成人心血管高凝状态患者中，FIX 水平升高是否是其发生血栓形成的危险因素。
方法
根据动脉短暂性脑缺血发作/脑卒中（TIA/脑卒中，n=62）或静脉血栓栓塞症（VTE，n=19）事件对患者进行分类。对所有 81 名患者和 40 名健康对照者进行 FIX 活性检测。
结果
62 例 TIA/脑卒中患者中有 13 例（21%）和 19 例 VTE 患者中有 5 例（26%）FIX 活性升高。FIX 活性升高患者发生 TIA/脑卒中及 VTE 的比值比分别为 3.7（95%置信区间 [CI]，0.76-17.65）和 6.8（95% CI，1.18-39.07）。
结论
我们的研究结果提示 FIX 水平升高与动脉和静脉血栓形成事件之间存在关联。
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