Tei K, Doi T, Sakai S, Fujimoto Y, Ban Y
Hinyokika Kiyo. 1985 Apr;31(4):731-8.
Sixteen patients with benign prostatic hypertrophy (BPH, 5 cases) and neurogenic bladder (NB, 11 cases) were treated with Robaveron tablets (KN-7) containing an extract of swine prostate gland 20 mg/T. at the dose of 2 tablets t.i.d. for a long term of 6-33 months. Evaluation of drug efficacy and safety were based on decrease of residual urine, improvement of subjective symptoms, complaints of side effects and clinical laboratory tests recorded every three months. Significant decrease of residual urine rate and good improvement of various subjective symptoms such as difficulty in urination, pollakisuria, urinary incontinence, etc. were obtained and maintained. The overall effectiveness, rated as slightly improved or better on the final evaluation of these cases was 68.8%. No cases of side effects or abnormal changes in the laboratory tests directly due to the test drug were observed. Robaveron tablet is both safe and effective for the long-term therapy of urinary disturbance.
16例良性前列腺增生(BPH,5例)和神经源性膀胱(NB,11例)患者接受了含有20mg/T猪前列腺提取物的Robaveron片(KN-7)治疗,剂量为每日3次,每次2片,疗程长达6 - 33个月。药物疗效和安全性评估基于残余尿量的减少、主观症状的改善、副作用主诉以及每三个月记录的临床实验室检查。残余尿量率显著降低,排尿困难、尿频、尿失禁等各种主观症状得到良好改善并得以维持。在这些病例的最终评估中,总体有效率(评为稍有改善或更好)为68.8%。未观察到直接由受试药物导致的副作用病例或实验室检查异常变化。Robaveron片对于泌尿系统紊乱的长期治疗既安全又有效。