Tokimasa T
Brain Res. 1985 Sep 30;344(1):134-41. doi: 10.1016/0006-8993(85)91197-7.
Neurons in bullfrog sympathetic ganglia were voltage-clamped using a single microelectrode. A prolonged outward current which was identified as the Ca-activated K-current secondary to a transient Ca entry through voltage-operated channels was shortened by oxotremorine. An inward Ca-current was not significantly depressed by oxotremorine. It was suggested that muscarinic agonists accelerate the re-closure of K-channels either directly or secondarily via their effects on an intracellular sequestration process of Ca ions. It was also suggested that a small amount of acetylcholine only sufficient to cause a miniature synaptic current via nicotinic receptors could shorten the Ca-activated K-current via muscarinic receptors.
使用单个微电极对牛蛙交感神经节中的神经元进行电压钳制。一种延长的外向电流被确定为继发于通过电压门控通道的短暂钙内流的钙激活钾电流，该电流被氧化震颤素缩短。内向钙电流未被氧化震颤素显著抑制。有人提出，毒蕈碱激动剂直接或继发于它们对钙离子细胞内螯合过程的影响，加速钾通道的重新关闭。也有人提出，仅足以通过烟碱受体引起微小突触电流的少量乙酰胆碱可通过毒蕈碱受体缩短钙激活钾电流。
