Rezin Gislaine T, Furlanetto Camila B, Scaini Giselli, Valvassori Samira S, Gonçalves Cinara L, Ferreira Gabriela K, Jeremias Isabela C, Resende Wilson R, Cardoso Mariane R, Varela Roger B, Quevedo João, Streck Emilio L
Laboratório de Bioenergética e Núcleo de Excelência em Neurociências Aplicadas de Santa Catarina (NENASC), Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
Mol Neurobiol. 2014 Apr;49(2):877-92. doi: 10.1007/s12035-013-8566-8. Epub 2013 Oct 15.
Fenproporex (Fen) is converted in vivo into amphetamine, which is used to induce mania-like behaviors in animals. In the present study, we intend to present a new animal model of mania. In order to prove through face, construct, and predictive validities, we evaluated behavioral parameters (locomotor activity, stereotypy activity, and fecal boli amount) and brain energy metabolism (enzymes citrate synthase; malate dehydrogenase; succinate dehydrogenase; complexes I, II, II-III, and IV of the mitochondrial respiratory chain; and creatine kinase) in rats submitted to acute and chronic administration of fenproporex, treated with lithium (Li) and valproate (VPA). The administration of Fen increased locomotor activity and decreased the activity of Krebs cycle enzymes, mitochondrial respiratory chain complexes, and creatine kinase, in most brain structures evaluated. In addition, treatment with mood stabilizers prevented and reversed this effect. Our results are consistent with the literature that demonstrates behavioral changes and mitochondrial dysfunction caused by psychostimulants. These findings suggest that chronic administration of Fen may be a potential animal model of mania.
芬普雷司（Fen）在体内可转化为苯丙胺，后者用于在动物中诱导类似躁狂的行为。在本研究中，我们旨在提出一种新的躁狂动物模型。为了通过表面效度、结构效度和预测效度进行验证，我们评估了接受芬普雷司急性和慢性给药、并用锂盐（Li）和丙戊酸盐（VPA）治疗的大鼠的行为参数（运动活动、刻板行为活动和粪便量）以及脑能量代谢（柠檬酸合酶、苹果酸脱氢酶、琥珀酸脱氢酶、线粒体呼吸链复合体I、II、II - III和IV以及肌酸激酶）。在大多数评估的脑结构中，芬普雷司的给药增加了运动活动，并降低了三羧酸循环酶、线粒体呼吸链复合体和肌酸激酶的活性。此外，使用心境稳定剂治疗可预防并逆转这种效应。我们的结果与文献一致，文献表明精神兴奋剂会导致行为改变和线粒体功能障碍。这些发现表明，芬普雷司的慢性给药可能是一种潜在的躁狂动物模型。
