B 类 G 蛋白偶联受体的结构：药物发现的前景。
Structures of class B G protein-coupled receptors: prospects for drug discovery.
机构信息
AG Chemical Genomics, Max Planck Institute of Psychiatry, Kraepelinstr. 2, München (Germany) http://www.mpipsykl.mpg.de/en/research/groups/hausch/index.html.
出版信息
Angew Chem Int Ed Engl. 2013 Dec 2;52(49):12783-5. doi: 10.1002/anie.201307542. Epub 2013 Oct 11.
New members in the GPCR photo gallery! Crystal structures of class B G protein-coupled receptors, which bind peptide hormones, have been solved [see picture of the corticotropin-releasing factor receptor 1 (blue) and a bound allosteric nonpeptide antagonist (green)]. The structures provide a basis for a rational design of better drugs for diabetes, osteoporosis, migraine, or depression.
GPCR 图片库迎来新成员！现已解析出结合肽类激素的 B 类 G 蛋白偶联受体的晶体结构[见图，促肾上腺皮质释放因子受体 1（蓝色）和结合的变构非肽类拮抗剂（绿色）]。这些结构为合理设计治疗糖尿病、骨质疏松症、偏头痛或抑郁症的更好药物提供了基础。
Zotero 插件