Chiba Y, Kawai K, Okuda Y, Munekata E, Yamashita K
Endocrinology. 1985 Nov;117(5):1996-2000. doi: 10.1210/endo-117-5-1996.
The effects of substance P (SP) and SP-(6-11) (SP6-11) on hormone secretion from the isolated perfused pancreas were compared in rats and dogs under the same conditions. In the rat, SP inhibited insulin secretion in a dose-dependent manner in a concentration range of 0.1-10 nM. Glucagon secretion was inhibited at a minimal dose of 10 nM SP. No significant effect on somatostatin secretion was obtained. SP6-11 exhibited the identical inhibitory potency as SP on both insulin and glucagon release from the rat pancreas. In the canine pancreas, by contrast, 1 and 10 nM SP and SP6-11, respectively, potentiated the release of insulin, glucagon, and somatostatin. Potentiation by SP6-11 was less than that by SP. These results demonstrate species differences in the effects of SP and SP6-11 on the release of pancreatic hormones.
在相同条件下，比较了P物质（SP）和SP -（6 - 11）（SP6 - 11）对大鼠和犬离体灌注胰腺激素分泌的影响。在大鼠中，在0.1 - 10 nM浓度范围内，SP以剂量依赖性方式抑制胰岛素分泌。胰高血糖素分泌在最低剂量10 nM SP时受到抑制。对生长抑素分泌未获得显著影响。SP6 - 11在大鼠胰腺胰岛素和胰高血糖素释放方面表现出与SP相同的抑制效力。相比之下，在犬胰腺中，1 nM和10 nM的SP以及SP6 - 11分别增强了胰岛素、胰高血糖素和生长抑素的释放。SP6 - 11的增强作用小于SP。这些结果表明SP和SP6 - 11对胰腺激素释放的影响存在种属差异。
