Maggi C A, Giuliani S, Santicioli P, Regoli D, Meli A
Eur J Pharmacol. 1985 Jul 17;113(2):291-4. doi: 10.1016/0014-2999(85)90750-2.
The effects of substance P and substance K on blood pressure, salivation and urinary bladder motility were investigated in urethane-anaesthetized rats. On intravenous administration, both peptides produced dose-related reductions in blood pressure, substance P being 25-30 times more potent than substance K. Substance P induced a dose-dependent increase of salivation, while substance K was half as active and induced only 40% of the maximum effect of substance P. The two tachykinins induced contractions of the urinary bladder, substance K being about twice as effective as substance P. Substance K was more effective than substance P in activating micturition. These findings provide further evidence that multiple receptor types are involved in mediating the effects of tachykinins in peripheral organs.
在乌拉坦麻醉的大鼠中研究了P物质和K物质对血压、唾液分泌和膀胱运动的影响。静脉给药时，两种肽均产生与剂量相关的血压降低，P物质的效力比K物质强25至30倍。P物质诱导唾液分泌呈剂量依赖性增加，而K物质的活性仅为P物质的一半，仅诱导出P物质最大效应的40%。两种速激肽均诱导膀胱收缩，K物质的效力约为P物质的两倍。K物质在激活排尿方面比P物质更有效。这些发现进一步证明，多种受体类型参与介导速激肽在外周器官中的作用。
