乳糖胺化白蛋白偶联的腺嘌呤-9-β-D-阿拉伯呋喃糖基-5-单磷酸在小鼠体内的药代动力学研究。
A study on the pharmacokinetics in mouse of adenine-9-beta-D-arabinofuranoside 5-monophosphate conjugated with lactosaminated albumin.
作者信息
Fiume L, Bassi B, Busi C, Mattioli A, Wieland T
出版信息
Experientia. 1985 Oct 15;41(10):1326-8. doi: 10.1007/BF01952078.
PMID:2412878
Abstract
In plasma of mice injected with adenine-9-beta-D-arabinofuranoside monophosphate (ara-AMP) coupled to human lactosaminated serum albumin (L-HSA) some of the ara-AMP molecules are enzymatically released, whereas others remain linked to L-HSA. Evidence has been obtained that ara-AMP is not deaminated when it is conjugated to L-HSA, in contrast to the free drug which is rapidly metabolized to its hypoxanthine derivative.
摘要
在注射了与人乳糖胺化血清白蛋白（L-HSA）偶联的腺嘌呤-9-β-D-阿拉伯呋喃糖基单磷酸酯（ara-AMP）的小鼠血浆中，一些ara-AMP分子会被酶促释放，而其他分子则仍与L-HSA相连。已经获得的证据表明，与游离药物迅速代谢为次黄嘌呤衍生物不同，ara-AMP与L-HSA结合时不会脱氨基。
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