Liu Qing-Xia, Guan Wei-Jie, Xie Yan-Qing, An Jia-Ying, Jiang Mei, Zhu Zheng, Guo E, Yu Xin-Xin, Liu Wen-Ting, Gao Yi, Zheng Jin-Ping
State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China and Qingyuan People's Hospital, Qingyuan, Guangdong, People's Republic of China.
State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
Respir Care. 2014 Jul;59(7):1071-7. doi: 10.4187/respcare.02739. Epub 2013 Oct 15.
Vibration response imaging (VRI) is a novel imaging technique and little is known about its characteristics and diagnostic value in idiopathic pulmonary fibrosis (IPF). The aim of this study was to investigate the features of VRI in subjects with IPF.
We enrolled 23 subjects with IPF (42-74 y old) and 28 healthy subjects (42-72 y old). Subjects with IPF were diagnosed by lung biopsy and underwent VRI, spirometry, lung diffusion testing, and chest x-ray or computed tomography, which entailed assessment of the value of VRI indices.
The total VRI score correlated statistically with single-breath carbon monoxide diffusing capacity percent predicted (r = -0.30, P = .04), but not with FVC percent predicted, FEV1 percent predicted, and FEV1/FVC (r = -0.27, -0.22, and 0.19; all P > .05). Compared with healthy subjects (17.9%), 20 subjects with IPF (86.96%, P < .01) presented with significantly increased crackles. The difference in quality lung data in all lung regions was unremarkable (all P > .05), except for the upper right and lower left lobes (P < .05). Overall, VRI parameters yielded acceptable assay sensitivity and specificity. Maximum energy frame was characterized by the highest diagnostic value (sensitivity, 1.00; specificity, 0.82), followed by presence of abundant crackles (sensitivity, 0.70; specificity, 0.96). Total VRI score was not a sensitive indicator of IPF, owing to low assay sensitivity (0.70) and specificity (0.64).
VRI may be helpful to discriminate between IPF subjects and healthy individuals. Maximum energy frame and abundant crackles might serve as a diagnostic tool for IPF.
振动反应成像（VRI）是一种新型成像技术，人们对其在特发性肺纤维化（IPF）中的特征和诊断价值知之甚少。本研究旨在探讨IPF患者的VRI特征。
我们纳入了23例IPF患者（年龄42 - 74岁）和28例健康受试者（年龄42 - 72岁）。IPF患者通过肺活检确诊，并接受了VRI、肺量计检查、肺弥散功能测试以及胸部X线或计算机断层扫描，对VRI指标的价值进行了评估。
VRI总评分与单次呼吸一氧化碳弥散量预测百分比具有统计学相关性（r = -0.30，P = 0.04），但与预测的FVC百分比、预测的FEV1百分比以及FEV1/FVC无相关性（r = -0.27、-0.22和0.19；所有P > 0.05）。与健康受试者（17.9%）相比，20例IPF患者（86.96%，P < 0.01）出现明显增多的啰音。除右上叶和左下叶外，所有肺区域的优质肺数据差异均不显著（所有P > 0.05）（P < 0.05）。总体而言，VRI参数具有可接受的检测敏感性和特异性。最大能量帧的诊断价值最高（敏感性为1.00；特异性为0.82），其次是存在大量啰音（敏感性为0.70；特异性为0.96）。由于检测敏感性（0.70）和特异性（0.64）较低，VRI总评分不是IPF的敏感指标。
VRI可能有助于区分IPF患者和健康个体。最大能量帧和大量啰音可能作为IPF的诊断工具。
